Judi
Verified Customer
I have started taking B-12 because my doctor recommended it from my blood tests. She said she takes this one after I asked her because there’s so many supplements out there. I love this product it has helped me with my energy levels. It is easy to take and the flavor is good. Definitely recommend it 😊

L-Methylfolate (15 mg) Plus Methyl-B12

L-Methylfolate (15 mg) Plus Methyl-B12

 (2586 Reviews)
$18.50
$18.50 $26.50
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  • Absorbs directly into the bloodstream and requires no processing from the body.
  • Contains the essential Cofactor MethylB12.
  • Supports brain and heart health and contributes to balancing energy, hormones, and mood

L-Methylfolate is the biologically active, bloodstream-ready form of Folate (Vitamin B9). Our formulation provides a maximum strength dose of 15 mg L-Methylfolate. This strength was formulated to support optimal folate levels. The formula also includes a whole serving of Methyl-B12, an essential cofactor to L-Methylfolate. The liquid sublingual form provides enhanced absorption and an enjoyable cherry flavor. It also contributes to the production of neurotransmitters, which are involved in maintaining focus, regulating sleep patterns, providing energy, balancing hormones, and impacting mood. Furthermore, Methylfolate promotes heart health and optimal nerve function.*

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Key Ingredients

  • Folate
  • Vitamin B12
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Size / Suggested Use

  • Size: 1 oz - 60 Servings
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Product Details

  • Absorbs directly into the bloodstream and requires no processing from the body.
  • Contains the essential Cofactor MethylB12.
  • Supports brain and heart health and contributes to balancing energy, hormones, and mood

L-Methylfolate is the biologically active, bloodstream-ready form of Folate (Vitamin B9). Our formulation provides a maximum strength dose of 15 mg L-Methylfolate. This strength was formulated to support optimal folate levels. The formula also includes a whole serving of Methyl-B12, an essential cofactor to L-Methylfolate. The liquid sublingual form provides enhanced absorption and an enjoyable cherry flavor. It also contributes to the production of neurotransmitters, which are involved in maintaining focus, regulating sleep patterns, providing energy, balancing hormones, and impacting mood. Furthermore, Methylfolate promotes heart health and optimal nerve function.*

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About this item

  • HIGH-POTENCY: Provides a high-potency serving of 15mg L-Methylfolate in the 5-MTHF calcium salt form. This bioactive form of folate is readily utilized by the body.
  • VITAL METHYL B12 COFACTOR: Methylcobalamin B12 and Methylfolate have co-dependent relationships that work together in the body's methylation processes. Methylfolate cannot complete the methylation process and breakdown of homocysteine without Methyl B12.
  • ACTIVE FORM OF FOLATE: Methylfolate is the most metabolically active and bloodstream-ready form of Folate or Folic Acid (vitamin B9). It is immediately absorbed into the bloodstream because it does not require processing or breakdown by the body. This is vital for those with methylation issues that cannot properly process folic acid.
  • SUPPORTS BRAIN, MOOD & ENERGY HEALTH: Important for healthy neurotransmitter function linked to focus, energy, and a balanced mood.
  • SUPPORTS CARDIOVASCULAR, NITRIC OXIDE & NERVE HEALTH: Helps maintain healthy homocysteine levels, promotes normal heart function, and supports nitric oxide production for overall circulatory and nerve well-being.

Healthy Methylation Plays A Role In Many Everyday Functions:

Mental Clarity*

Emotional Balance*

Cellular Energy Production*

Healthy Hair*

Skin Health*

Energy Metabolism*

Emotional Well-being*

Stress Response*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Up to 40% of people may carry a common MTHFR gene variant.* 

Methylated Folate: A Nutrient Form Some People Prefer for Genetic Support*

Certain MTHFR gene variations may affect how the body processes synthetic folic acid. Methylated forms like 5-MTHF can offer a more direct form of folate support.

Methylated vitamins provide folate in a body-ready form, supporting bioavailability and cellular use.*

Why You’ll Love Our L-Methylfolate

Enhanced with B12*

Designed for Efficient Absorption*

Bloodstream Ready L-Methyfolate*

No Conversion Required - Body-Ready Form*

How L-Methylfolate Works in the Body

  • Supports red blood cells production and detox in the body.*

  • Supports neurotransmitters like serotonin, dopamine & norepinephrine.*

  • Helps your homocysteine levels stay in check which is vital for heart and brain health.*

    Body-Ready Nutrients in One Easy Dose

    Supports Heart Health*

    Supports Nerve Cognition*

    Supports Mood & Cognition*

    Supports Healthy Methylation*

    *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

    How to Take L-Methyfolate

    1.Shake well before use.

    2. Take 10 droplets directly under tongue 

    OR mix 10 droplets into your favorite drinks, smoothies or water.

    Know your supplement

    Our drops are a deep, rich burgundy shade. Please be cautious of counterfeit products that may differ in color or quality. To ensure you receive a genuine product, only purchase from our official websites or stores.

    Results Over Time

    • 3-7 Days: Gradual Support*

      Some individuals may begin to notice support for mental clarity, mood balance, and energy. This is also when nutritional support for red blood cell formation and homocysteine metabolism may begin.*

    • Weeks 4-8: Noticeable Support*

      Neurotransmitter production for the ‘feel good’ hormones like serotonin & dopamine goes up which can help with an improvement in mood and a reduction in symptoms of anxiety.*

    • Month 3-6: Ongoing Support*

      Some individuals may notice more consistent energy levels and support for healthy eating patterns. Users have also shared feeling more in tune with their overall wellness goals and daily routines.*

      Hear From Our Experts

      "As a health researcher, I view L-Methylfolate as an essential nutrient for neurological, emotional, and metabolic balance—especially in individuals with genetic variants like MTHFR. Triquetra’s L-Methylfolate line stands out for its clinically relevant dosing, exceptional purity, and highly bioavailable formulas, with options tailored for both adults and children. It’s a science-backed choice for those seeking therapeutic efficacy and uncompromising quality."

      Adriano Zanardi da Silva, M.Sc., Ph.D

      Quality Standards You Can Trust

      Warning:If you have a medical condition or are taking medication, contact a physician before taking this supplement. Keep out of reach of children.

      *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

      Frequently Asked Questions

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      What is L-Methylfolate and how is it different from folic acid?

      L-Methylfolate is the active form of folate that your body can use immediately. Folic acid needs to be converted—and some people can’t do that well because of genetic mutations like MTHFR.

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      What is Methyl B12 and why is it paired with L-Methylfolate?

      Methyl B12 (aka Methylcobalamin) is a highly bioavailable form of B12 that works synergistically with L-Methylfolate to support brain health, energy, and mood.

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      Is this product safe if I’m pregnant or breastfeeding?

      Check with your doctor first. L-Methylfolate is often recommended during pregnancy, but always confirm with your healthcare provider.

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      Can this supplement interact with medications?

      It is possible L-Methylfolate may interact with certain medications. It is always best to check with a healthcare provider before starting any supplements.

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      Are there any known side effects?

      Most people tolerate it well. If you feel like you are sensitive to higher doses, you can work your way up to the full dose over time.

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      How do I take it — with food or without?

      It can be taken with or without food, but some people prefer it with a meal to avoid mild stomach discomfort.

      Reviews From Some Of Our Happy Customers

      I have started taking B-12 because my doctor recommended it from my blood tests. She said she takes this one after I asked her because there’s so many supplements out there. I love this product it has helped me with my energy levels. It is easy to take and the flavor is good. Definitely recommend it 😊

      Judi

      VERIFIED PURCHASE

      I’ve been using Triquetra Health’s L-Methylfolate 5-MTHF + Methyl B12 every single day for over a year now, and I truly won’t go without it. As someone in long-term recovery, supporting my mental clarity, mood, and energy naturally is a top priority—and this supplement has been a crucial part of that.

      Sami

      VERIFIED PURCHASE

      I had been searching for an alternative to B12 shots and found came across this methyl b12. Within the first week of using this product, I was sold. The clean energy and mood enhancement these supplements brought to my daily routine has been life changing. I literally recommend these to everyone bc they are effective and affordable.

      Amanda

      VERIFIED PURCHASE

      This is my second bottle of L-Methylfolate and I have turned my family onto it. Mild depression runs in our family and while there are multiple possible sources, including trauma, I want to address nutritional causes by giving myself and my family the vitamins and minerals our bodies need to biologically run optimally. And this product is one of the easiest ways to address a possible cause.

      Yung

      VERIFIED PURCHASE

      It’s a liquid blend of L-methyl folate—already in that active 5-MTHF form—plus methylcobalamin, the active version of B12. No conversion needed. A dropperful on or under your tongue is like giving your body the tools it’s been asking for, especially if you’re one of those 60% with that genetic hiccup. A few drops a day, and you’re supporting your methylation cycle—your heart, your brain, your energy—all without another pill to swallow.

      Bryan

      VERIFIED PURCHASE

      I LOVE THIS FORMULA! I will start to notice a nice boost in energy within the hour of taking this. You put 5 drops under your tongue and let it sit for 30 seconds. I have used other 5-MTHF pills that were double the dosage of Folate & B12 and still prefer this, as I do feel like it does they job better. This is a great product and brand!!! The hype I saw on Tiktok about this is real. Also, lab work has confirmed this works! Try it and see for yourself. :)

      Nicolette nunes-horyst

      VERIFIED PURCHASE

      I have started taking B-12 because my doctor recommended it from my blood tests. She said she takes this one after I asked her because there’s so many supplements out there. I love this product it has helped me with my energy levels. It is easy to take and the flavor is good. Definitely recommend it 😊

      Judi

      VERIFIED PURCHASE

      I’ve been using Triquetra Health’s L-Methylfolate 5-MTHF + Methyl B12 every single day for over a year now, and I truly won’t go without it. As someone in long-term recovery, supporting my mental clarity, mood, and energy naturally is a top priority—and this supplement has been a crucial part of that.

      Sami

      VERIFIED PURCHASE

      I had been searching for an alternative to B12 shots and found came across this methyl b12. Within the first week of using this product, I was sold. The clean energy and mood enhancement these supplements brought to my daily routine has been life changing. I literally recommend these to everyone bc they are effective and affordable.

      Amanda

      VERIFIED PURCHASE

      This is my second bottle of L-Methylfolate and I have turned my family onto it. Mild depression runs in our family and while there are multiple possible sources, including trauma, I want to address nutritional causes by giving myself and my family the vitamins and minerals our bodies need to biologically run optimally. And this product is one of the easiest ways to address a possible cause.

      Yung

      VERIFIED PURCHASE

      It’s a liquid blend of L-methyl folate—already in that active 5-MTHF form—plus methylcobalamin, the active version of B12. No conversion needed. A dropperful on or under your tongue is like giving your body the tools it’s been asking for, especially if you’re one of those 60% with that genetic hiccup. A few drops a day, and you’re supporting your methylation cycle—your heart, your brain, your energy—all without another pill to swallow.

      Bryan

      VERIFIED PURCHASE

      I LOVE THIS FORMULA! I will start to notice a nice boost in energy within the hour of taking this. You put 5 drops under your tongue and let it sit for 30 seconds. I have used other 5-MTHF pills that were double the dosage of Folate & B12 and still prefer this, as I do feel like it does they job better. This is a great product and brand!!! The hype I saw on Tiktok about this is real. Also, lab work has confirmed this works! Try it and see for yourself. :)

      Nicolette nunes-horyst

      VERIFIED PURCHASE

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